Effects of trypanosomosis on hemogram and some biochemical parameters of guinea pigs experimentally infected with Trypanosoma brucei brucei in Maiduguri, Nigeria

A M Abdullahi,A W Mbaya,U I Ibrahim,D Iliyasu,I Wiam,H B Galadima

doi:10.30574/gscbps.2019.7.1.0007

A M Abdullahi, A W Mbaya + Show 4 more

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https://doi.org/10.30574/gscbps.2019.7.1.0007

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Abstract

The study was designed to evaluate the effect of tryponosomosis on hemogram and some biochemical parameters of guinea pigs. Guinea pigs of both sexes weighing (5-10 kg) were divided into six groups (A, B, C, D, E and F) with five guinea pigs in each group. At day zero, to establish the baseline data, all the animals in each of the six groups were bled for haematology and serum biochemistry and also clinical parameters (rectal temperature, respiratory rate, pulse rate and heart beats) were recorded while general body condition and physical signs were also evaluated. Groups A, B and C were intraperitoneally (IP) inoculated with 1×106 dose of Trypanosoma brucei brucei contained in 0.5 ml of blood. Thereafter, blood samples were collected every other four (4) days for evaluation of hematology and serum electrolytes through the experimental period. Group D, E and F was uninfected control. All the infected groups (A, B, and C) had a pre-patent period of 16 days with similar levels of parasitaemia of 45.7±3.38 across the groups. The observed clinical signs among the infected groups (A, B and C) were pyrexia, pale feet, snout, pinnae and mucous membrane, anaemia, dullness, emaciation and loss of weight. In group A, a mean parasitaemia of 2.8 ± 0.84 occurred by day 16 post-infection post infection which continued to rise significantly without abating (p 0.05). Dose of Veriben® administered at the dose rate of 7.0 mg/kg and 3.5 mg/kg have the abilities of curbing the state of anaemia, immunosuppression, and serum electrolytes levels in trypanosome-infected guinea pigs placed on a dose dependent manner.

Highlights

Trypanosomosis is one of the most important zoonotic disease commonly found in Africa regions and South America [1]
In group A, a mean parasitaemia of 2.8 ± 0.84 occurred by day 16 post-infection post infection which continued to rise significantly without abating (p
Dose of Veriben® administered at the dose rate of 7.0 mg/kg and 3.5 mg/kg have the abilities of curbing the state of anaemia, immunosuppression, and serum electrolytes levels in trypanosome-infected guinea pigs placed on a dose dependent manner

Summary

Introduction

Trypanosomosis is one of the most important zoonotic disease commonly found in Africa regions and South America [1]. African trypanosomosis is caused by a protozoan parasite belonging to the genus Trypanosoma, and is transmitted by tsetse flies to the final host. The disease is characterised by high morbidity and mortality of infected livestock. Animal trypanosomosis has been estimated to cost Africa about US$ 4.5 billion per year [2]. Trypanosomosis affect almost all vertebrates man and livestock. Wild animals such as Bovidae and suidae, act as asymptomatic carriers

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