Abstract
IN 1952, we initiated a programme directed toward the synthesis and biological evaluation of a variety of triphenylmethane derivatives as potential schistosomicides in the hope that a useful curative drug could be developed. To date, more than two hundred have been tested in albino mice and several in rhesus monkeys experimentally infected with a Puerto Rican strain of Schistosoma mansoni. Several compounds have also been tested against the lung fluke Paragonimus kellicotti in dogs. In the summary presented below, all amounts of drug are expressed as carbonium ion.
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