Effects of trimetazidine, a myocardial metabolism agent, on regulating 5-hydroxytrytamine system of rats with myocardial infarction and/or depression

Abstract

Objective: 5-Hydroxytrytamine (5-HT) system was reported to be associated with myocardial infarction (MI) and depression. The aim of the present study was to study the effect of trimetazidine on 5-HT in MI and/or depression rats. Methods: Ninety rats were divided into three groups: trimetazidine, sertraline and saline groups (n=30 in each group), and pretreated with trimetazidine, sertarline, or saline, respectively, by gavage once a day for 4 weeks. Thereafter, each group was further divided into three subgroups: MI subgroup, depression subgroup, and MI+ depression subgroup. Serum 5-HT, platelet 5-HT, 5-HT(2A) receptor (5-HT(2A)R), and serotonin transporter (SERT) were detected by enzyme linked immunosorbent assay. Results: Similar to sertarline, comparing to saline, trimetazidine treatment increased serum 5-HT [(221±23) pg/ml vs. (176±11) pg/ml; (395±31) pg/ml vs. (195±5) pg/ml; (348±28) pg/ml vs. (183±10) pg/ml], platelet 5-HT [(305±22) pg/ml vs. (130±27) pg/ml; (252±18) pg/ml vs. (175±5) pg/ml; (241±26) pg/ml vs. (181±11) pg/ml], and platelet 5-HT(2A)R levels [(247±13) pg/ml vs. (197±12) pg/ml; (320±13) pg/ml vs. (193±18)pg/ml; (334±17) pg/ml vs. (206±15) pg/ml]), and lowered platelet SERT levels [(248±11) pg/ml vs. (323±36) pg/ml; (188±7) pg/ml vs. (278±20) pg/ml; (170±23) pg/ml vs. (282±22) pg/ml] in MI, depression and MI+ depression subgroups, respectively (all P< 0.05). When compared the effect of trimetazidine and sertarline treatment, serum 5-HT and platelet 5-HT(2A)R in MI group were significantly lower in trimetazidine than in sertraline group (P<0.05), while serum 5-HT and platelet 5-HT, 5-HT(2A)R in depression group rats were significantly higher in trimetazidine than in sertraline group (P<0.05).Interestingly, platelet 5-HT(2A)R in MI+ depression rats was much higher in trimetazidine than in sertraline group (P<0.05). Conclusions: Trimetazidine, a kind of myocardial metabolism agent, could play a role on the regulation of 5-HT, 5-HT(2A)R, and SERT levels in rats with MI and/or depression.