Abstract
Effects of Trigonella Foenum Greacum in Combination with Ginger Zingiber Officinale on Nephrotoxicity in an Alloxan-Induced Diabetic Rats model
Highlights
The Diabetes mellitus is a common disease related to an increased death rate
Forty rats were divided into four groups; normal control rats, diabetic control rats, diabetic rats treated Trigonella foenumgreacum (TFG) in combination with GZO, and diabetic rats treated with glibenclamide as a positive control
The results of this study showed that diabetes mellitus induced by alloxan produced pronounced nephrotoxic effects, with a significant increase in the concentration of serum glucose and creatinine concentration, with a significant decrease in total proteins
Summary
The Diabetes mellitus is a common disease related to an increased death rate. Diabetes mellitus is a disorder of metabolic illness described by hyperglycemia coming about because of defects in insulin production, insulin activity, or both, altered metabolism of carbohydrates, lipids, and proteins, and extends to vascular disease complications [1,2,3]. Dyslipidemia is likewise a significant risk factor for atherosclerotic patients with type-2 diabetes mellitus. Dyslipidemia in a diabetic patient is described by moderate hypertriglyceridemia and reduced high-density lipoprotein (HDL) cholesterol levels [4]. Diabetes induced by alloxan leads to beta cell-specific necrosis, insulin reduction, increase reactive oxygen species (ROS) in the status of alloxan mediated the toxic
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