Effects of Triamcinolone on Dialysis of Kidney Mercury in Chicks Resistant and Susceptible to Leukosis ,

Abstract

MILLER et al. (1959a, b, 1967) have reported that one strain of inbred chicks (R) retained more mercury in the liver and kidneys than another strain (S) following injection of mercuric chloride (MC) or phenylmercuric acetate. These lines were selected for resistance (R) and susceptibility (S) to the avian leukosis complex by Bearse et al. (1963). A triamcinolone diacetate (TR) injection of 1.0 mg. per kg. body weight given 24 hours before MC had been found to increase the retention of mercury in the kidneys of the R chicks 96 hours later (Miller et al., 1969). Since mercury was deposited primarily in the kidney, this paper reports some aspects of the stability of the kidney-mercury complex based on the percentage of the mercury dialyzable against dilute thiomalate (TM) from kidney homogenates of both strains. The effect of preinjection of TR on the percent of dialyzable mercury is also reported.METHODS.