Abstract
Tremorine produced pronounced tremor, akinesia, hypothermia and parasympathetic effects in young chicks. Tremor was recorded quantitatively and the tremor response to tremorine was found to diminish with increasing age and with repeated dosage. The optimal age of the chicks for obtaining a tremor response to tremorine was 3 to 4 days. Harmine also produced tremor, and some akinesia and hypothermia. The harmine effect did not diminish with age or with repeated dosage. Tremorine produced a significant increase in the brain levels of acetylcholine, and a decrease in the brain levels of noradrenaline. It did not affect the levels of tyramine, dopamine or ergothioneine. Harmine produced an increase in the brain levels of noradrenaline but did not affect the levels of acetylcholine, tyramine or ergothioneine.
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