Abstract
Intraperitoneal treatment of female AKR mice from the 10th week of life with 400 μg/mouse poly(rl) caused significant prolongation of life and a greater effect occurred with weekly treatments of 100 or 400 μg/mouse poly(rI) followed 4 h later by 100 or 400 μg/mouse poly(rC). Treatment with 750 μg/mouse poly(rA).poly(rU) from the 20th week did not significantly prolong life and treatment with poly(rA) alone at 400 μg/mouse/week caused death to occur significantly earlier. Direct assays showed that the treatments with single-stranded polynucleotides did not induce circulating interferon and these treatments also failed to “hyporeactivate” the protective effect of poly(rI).poly(rC) to encephalomyocarditis virus infection of AKR mice. Effects on viral reverse transcriptase activity are considered and related to possible human prophylaxis.
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