Abstract
ObjectiveTo explore the effects of transient electric acupuncture stimulation combined with rehabilitation training on hemorheology, neurological function and brain-derived neurotrophic factor (BDNF) in patients with cerebral infarction (CI).MethodsA total of 90 patients with CI were admitted to our hospital from March 2019 to March 2021. According to the random number table method, 90 patients were divided into a control group (was treated with transient electrical acupuncture stimulation intervention treatment) and a therapy group (was treated with rehabilitation training on the basis of the control group), with 45 cases in each group. NIHSS score to detect neurological deficit; FMA score to detect motor function recovery; the clinical efficacy of the two groups of patients were compared; blood rheology analyzer to detect whole blood high shear viscosity, whole blood low shear viscosity, platelet aggregation rate and fibrinogen indicators; ELISA detects the content of BDNF in serum.ResultsThere was no significant difference in NIHSS score, FMA score, clinical efficacy, hemorheology index, and BDNF content between the two groups of patients before treatment (P > 0.05). After treatment, the NIHSS score, whole blood high shear visible, whole blood low shear visible, platelet aggregation rate and fibrinogen index of the two groups were lower than those before treatment, and the FMA score and BDNF content of the two groups were higher than those before treatment, and all the above indicators in the therapy group changed significantly compared with the control group (P < 0.05). After treatment, the clinical efficacy of the therapy group was better than that of the control group (P < 0.05).ConclusionThe combination of transient electrical acupuncture stimulation and rehabilitation training can inhibit the blood flow index of patients with CI, improve the nerve function, increase the content of BDNF in the patient's serum, and restore the patient's nerve function.
Highlights
Cerebral infarction (CI), known as ischemic stroke, accounts for 65–70% of the total number of strokes in my country, and is an acute and critical illness of cerebrovascular disease
Cerebral infarction is mainly due to cerebral hemodynamic disturbance and local brain tissue is in a state of ischemia and hypoxia, which can cause serious damage to the neurological function of the brain of patients [1]
More than 75% of patients with CI still have different degrees of dysfunction even after the brain tissue is restored to perfusion, which seriously affects the quality of life of the patients
Summary
Cerebral infarction (CI), known as ischemic stroke, accounts for 65–70% of the total number of strokes in my country, and is an acute and critical illness of cerebrovascular disease. Rehabilitation training can increase the expression level of nerve growth factor in patients with CI, stimulate the auxiliary motor cortex, and improve brain function, thereby restoring or partially restoring the control of the brain to the subcortical center and improving the motor function of the limbs [3, 4]. Brain-derived neurotrophic factor (BDNF) is one of the most representative members of the nerve growth factor family. It is a basic protein with a relative molecular weight of 12,300, with the highest content in the hippocampus [6]. In this study, combined use of transient electrical acupuncture stimulation combined with rehabilitation training to observe its effects on hemorheology, neurological function and BDNF in patients with CI
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