Effects of transcutaneous electrical acupoint stimulation at different frequencies on perioperative anesthetic dosage, recovery, complications, and prognosis in video-assisted thoracic surgical lobectomy: a randomized, double-blinded, placebo-controlled trial.

Abstract

Transcutaneous electrical acupoint stimulation (TEAS), a non-invasive and non-pharmacological adjunctive intervention for perioperative analgesia, may also reduce the incidence of postoperative pulmonary complications. The effect of TEAS on video-assisted thoracic surgical (VATS) patients is still unknown, however. The purpose of this study was to investigate the effects of TEAS of different frequency on perioperative anesthetic dosage, recovery, complications, and prognosis for patients undergoing VATS lobectomy. Eighty VATS lobectomy patients with no previous experience of TEAS or acupuncture were randomly assigned to four groups: control (con), 2/100, 2, and 100Hz. The last three experimental groups received TEAS at the indicated frequencies for 30min before induction, during the operation, and for another 30min 24 and 48h after surgery. 2/100Hz is a type of alternating frequency which goes between 2 and 100Hz every 3s. TEAS was administered over acupoints Neiguan, Hegu, Lieque, and Quchi on the sick lateral. Electrodes were applied to the patients in the control group, but no TEAS was used. Anesthetic dosage, blood gas analysis results, lung function indexes FEV1 and FVC, post-anesthesia care unit (PACU) status, postoperative complications, and quality of life scores were recorded and analyzed statistically. Intraoperative opioid consumption was lowest in the 2/100Hz group, with statistical significance (con, P≤0.001; 2Hz, P≤0.001; 100Hz, P=0.026). Compared with preoperative FEV1 and FVC, postoperative FEV1 and FVC were significantly lower in all groups; during one-lung ventilation, arterial oxygen partial pressure (PaO2) decreased more slowly in the 2/100Hz group than in the con group (P=0.042). Moreover, in the 2/100Hz group extubation time was shorter (P=0.038), visual analgesia scale score lower (P=0.047), and duration of PACU stay shorter (P=0.043) than in the con group. In the 100Hz group incidence of postoperative nausea and vomiting (PONV) was lower than the con group (P=0.044). In all groups mean postoperative physical component scores were significantly lower than mean preoperative scores. TEAS is a safe noninvasive adjunctive intervention for anesthesia management among patients undergoing VATS lobectomy. TEAS at 2/100Hz can reduce intraoperative opioid dosage and slow the decrease of PaO2 during one-lung ventilation. It can also effectively reduce pain score, extubation time, and PACU stay immediately after surgery. Further, 100Hz TEAS can reduce PONV morbidity.