Year-end Sale % OFF 
Abstract
We examined the effects of the timing of acute and consecutive epigallocatechin gallate (EGCG) and catechin-rich green tea ingestion on postprandial glucose in mice and human adults. In mouse experiments, we compared the effects of EGCG administration early (morning) and late (evening) in the active period on postprandial glucose. In human experiments, participants were randomly assigned to the morning-placebo (MP, n = 10), morning-green tea (MGT, n = 10), evening-placebo (EP, n = 9), and evening-green tea (EGT, n = 9) groups, and consumed either catechin-rich green tea or a placebo beverage for 1 week. At baseline and after 1 week, participants consumed their designated beverages with breakfast (MP and MGT) or supper (EP and EGT). Venous blood samples were collected in the fasted state and 30, 60, 120, and 180 min after each meal. Consecutive administration of EGCG in the evening, but not in the morning, reduced postprandial glucose at 30 (p = 0.006) and 60 (p = 0.037) min in the evening trials in mice. In humans, ingestion of catechin-rich green tea in the evening decreased postprandial glucose (three-factor analysis of variance, p < 0.05). Thus, catechin intake in the evening more effectively suppressed elevation of postprandial glucose.
Highlights
Postprandial hyperglycemia is related to the development of diabetes and cardiovascular disease [1,2,3]
Previous our studies reported that this specific amount of catechin resulted in decreased postprandial glucose concentrations in humans [17,18]
Mann-Whitney tests showed that the concentrations of glucose in the epigallocatechin gallate (EGCG) group at fasting state (p = 0.006), 15 min (p = 0.006), 30 min (p = 0.006), and 60 min (p = 0.017) after corn starch (CS) administration were significantly lower than those in the control group for the morning trials
Summary
Postprandial hyperglycemia is related to the development of diabetes and cardiovascular disease [1,2,3]. Nutrients 2020, 12, 565 concentrations are higher in the evening than in the morning [6,7,8]. The time-of-day variations in glucose tolerance, including insulin function, have been observed, peaking in the morning and with a minimum in the evening/night. The mechanisms underlying the time-of-day variations in glucose tolerance are caused by the circadian system, which mediates time-of-day variations in digestion, absorption, and metabolism in the stomach and intestines [9,10]. Several transporters related to the absorption of glucose, including sodium/glucose cotransporter 1 (SGLT1), glucose transporter
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
