Abstract
This study aims to assess the safety, feasibility, and effectiveness of 10-hr Time-Restricted Eating (TRE) compared to ad libitum eating on anthropometric measurements, cardiometabolic and cardiovascular health in patients with Acute Coronary Syndrome (ACS). The Time-Restricted Eating Study (TRES) is a single-centre, pragmatic, prospective, randomised controlled trial that will include 48 patients with ACS. Participants will be randomised in a 1:1 ratio to the intervention group where eating duration is restricted to 10 hours per day or control group with no limitation of eating duration imposed. Testing is scheduled at baseline and after four weeks of intervention. The primary outcome is change in body weight after four weeks of intervention. Secondary outcomes include changes in body composition, glycaemic and lipid profiles, inflammatory markers, oxidative stress, endothelial function, arterial stiffness, blood pressure, heart rate, safety, and feasibility of TRE on patients with ACS. The study was approved by the UiTM Research Ethics Committee. Findings will be disseminated through manuscripts, reports, and presentations. Findings on the feasibility and effectiveness of TRE in patients with ACS may broaden the body of evidence for implementing TRE as a dietary intervention to prevent secondary cardiovascular diseases.
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