Abstract
Objective: to evaluate the effects of tibolon on serum lipoprotein (a) levels in patients with surgical menopause . Materials and methods: Forty-sixpremenopausal women (mean age 42 ± 5,1) undergoing surgical menopause were included in the study and transdermal estradiol was started 10 days after surgery. Serum lipids including lipoprotein(a) were measured before and after the surgery for 1 year with 3 month- intervals. Tibolone was added to the therapy in patients with serum concentration of lipoprotein (a) greater than 30 mg/dl. Results: Thirty-five women were still under follow-up at the end of 12 months. In 19 of them lipoprotein(a) levels increased despite transdermal estradiol. Lipoprotein (a) level before transdermal estradiol therapy was 17,7 ± 7. Serum lipo¬protein (a) levels at the 3rd month, 6th month, 9th and 12th month of transdermal estrogen therapy were 33,1 ± 29,4, 54,6 ± 28,4 (p
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