Abstract
In hyperthyroid rats, hepatic levels of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) were not increased above normal despite increased activity of the enzymes FAD pyrophosphorylase and flavokinase responsible for their synthesis. The activity of FMN phosphatase, which degrades FMN, was also slightly increased. Mechanisms which may account for the apparent upper limit in FMN and FAD levels in hyperthyroidism have been discussed. In hypothyroid rats, hepatic concentrations of FMN and FAD were reduced below normal. In these animals there were no changes in the activity of either FAD pyrophosphorylase or FMN phosphatase. These data provide additional evidence that the decreased hepatic concentrations of FMN and FAD in hypothyroidism may be related to the previously reported decrease in activity of flavokinase, which converts riboflavin to FMN. (Endocrinology 84: 584, 1969)
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