Abstract
The effects of synthetic TRH and methyl TRH (pGlu-N3imMe-His-Pro-NH2) in maternal, fetal and newborn rats were investigated. Colloid droplet (CD) formation in the thyroid cell was enumerated as the index of thyroid hormone secretion induced by TSH. TSH concentration in the serum and pituitary was measured by a homologous radioimmunoassay of rat TSH. 10 fig TRH injected into the maternal tail vein increased the CD in the maternal thyroid from 12⁄25 follicles (control) to 442 μ 20⁄25 (SE) and in the 21 day fetal thyroid from 1⁄25 to 129 μ 12⁄25. 1 μg methyl TRH injected iv to the mother also increased CD in the maternal thyroid and fetal thyroid to 754⁄25 and 76⁄25, respectively. TSH injected to the mother stimulated maternal CD and did not affect the fetal CD. TSH levels in maternal serum at 30 min after administration of 10 μg TRH or 1 μg methyl TRH increased from 20 μU⁄ml to 442 nU⁄ml and 382 μU⁄ml, respectively. Administration of 10 pig TRH to the mother did not cause significant depletion of the pituit...
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