Abstract
Larvae ofSalamandra salamandra quadrivirgata Durigen and tadpoles ofXenopus laevis Daud, treated with a percutaneous application of thyroxin, show a more intensive calcification of their skeletal system after a precocious metamorphosis. The calcified area of bones is increased; additional centres of calcification can be distinguished in quite a number of other skeletal elements. By thyroxin-soaked agar implants in the hindlimbs ofAmbystoma mexicanum, deposition of calcium salts is furthered in the bones of the leg treated, as well as in the adjacent pelvic girdle, thus demonstrating that the thyroid hormone exerts a direct effect upon calcification. It is supposed that during normal metamorphosis the thyroid gland plays an equal part in the process of calcification in the skeletal system.
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