Effects of three infusion fluids with different sodium chloride contents on steady-state serum concentrations of bromide in dogs.

Abstract

Potassium bromide overdose (bromism) in the management of canine epilepsy has been known. However, a protocol to reduce bromide concentrations rapidly has not been previously established. The effects of three infusion fluids with different chloride contents on the steady-state serum concentrations of bromide in beagles were determined. After stabilization of the serum bromide concentrations, seven dogs were infused with saline (Na+ 154mmol/L; Cl- 154mmol/L), lactated Ringer's (Na+ 131mmol/L; Cl- 110mmol/L), or maintenance solutions (Na+ 35mmol/L; Cl- 35mmol/L) at a rate of 2 or 10mlkg-1 hr-1 for 5hr. Serum and urine were collected hourly, and the bromide concentrations were measured. When saline and lactated Ringer's solutions were infused at a rate of 10mlkg-1 hr-1 for 5hr, serum bromide concentrations were decreased by 14.24% and urine bromide concentrations by 17.63%, respectively. Of all compositions of infusion fluids, only sodium and chloride contents were associated with the decreased serum concentrations and the increased renal clearance of bromide. In summary, saline and lactated Ringer's solutions reduced serum bromide concentrations in a sodium chloride-dependent manner in dogs were found when infused at 10mlkg-1 hr-1 for 5hr.