Abstract
The effects of acoustic waves on membrane structures, and any resulting consequences of this treatment on membrane subunit structures, remain poorly understood, as are the principals of related clinical effects. With a focus on morphological changes in the nuclear envelope, the current study presents detailed observations of membrane structures exposed to therapeutic ultrasound. Ultrasound treatment most commonly resulted in distinct changes in the distribution of nuclear pore complexes (NPCs) and mean NPC number per unit area after 30 min of repair, as well as alterations in NPC diameters on the protoplasmic face of fractured nuclear membranes after 10 min of repair. The greatest effects of ultrasound on nuclear envelope structure and NPCs were not to appear immediately, but became evident after repair processes were initiated. Results from the current study may contribute to the general view on the biophysical effects of therapeutic ultrasound on cell morphology and, particularly, the understanding of this effect in relation to the nuclear envelope.
Highlights
Ultrasound, as a physical factor, is frequently used in routine medicine, at the cellular level, the effects of acoustic waves on cell membranes are not fully understood
The nuclear envelope is a complex dynamic system composed of membranes and proteins that, when treated by therapeutic ultrasound, are exposed to acoustic waves
Based on literature and results of our previous studies on nuclear membranes treated with therapeutic ultrasound, we focused, in the first place, on fractures through nuclear pore complexes
Summary
As a physical factor, is frequently used in routine medicine, at the cellular level, the effects of acoustic waves on cell membranes are not fully understood. © Journal of Applied Biomedicine biophysical effects on cells and tissues are used in physical therapy. The nuclear envelope is a complex dynamic system composed of membranes and proteins that, when treated by therapeutic ultrasound, are exposed to acoustic waves. The membraneacoustic wave interaction results in biophysical changes in protein structures, subsequently leading to functional changes detectable by molecular biology and biophysics techniques. These changes initiate a cascade of secondary processes, eventually leading to a therapeutic result
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