Abstract
Salicyclic acid flux at pH 7.4 across rat jejunum was measured before and after perturbation with theophylline and/or an electric field. After the flux reached a steady state control condition theophylline was added to the system, which resulted in establishment of a new higher steady state flux. Dependence of flux on an externally applied potential difference was observed to have a strong exponential behavior. It appears that salicylate transport is primarily via the shunt pathway and the effect of theophylline is to increase transport by the low resistance pathway.
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