Effects of the Trier Social Stress Test on the distributions of IL-6 and MAP levels

Abstract

Trier Social Stress Test (TSST) is an experimental psychological test that induces changes in autonomic, endocrinological and immunological activity. Two measures used to evaluate the inflammatory activity induced by this test are the interleukin 6 (IL-6), a cytokine sensitive to changes in sympathetic nervous activity, and the mean arterial pressure (MAP), a measure sensitive to changes in autonomic activity. This study had two goals: first, the study examined whether TSST increases IL-6 and MAP levels; second, pre- and post-TSST IL-6 levels were compared for participants whose IL-6 levels increased or decreased due to the TSST. Saliva samples of IL-6 and MAP were taken from 42 participants clinically healthy, without psychiatric history, and data were analysed via quantile comparisons. The results showed that TSST did not lead to an increase in sympathetic activity as indexed by IL-6. Instead, TSST led to increases in MAP. Also, there were significant differences between the IL-6 distributions of people whose IL-6 levels changed from low to high (63%) and from high to low (37%) before and after the TSST. These findings suggest that the TSST will not have the same effect on all participants; that is, individual differences can be assessed using a biomarker to identify people with specialized psychological care needs.