Effects of the Treatment of Dong Medicine Five-Flavour Anti-Diarrhoea Soup Combined with Melalazine on Serum Complement C3, C4, Interleukin-23 and Interleukin-17 in Patients with Ulcerative Colitis

Abstract

To investigate the clinical effect of the treatment of dong medicine five-flavor anti-diarrhea soup combined with melalazine on the chronic recurrence type (spleen deficiency and dampness accumulation type) ulcerative colitis. A total of 60 patients conforming to the diagnostic criteria of traditional Chinese and Western medicine in the anorectal department and gastroenterology department of the First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine from September 2019 to December 2020 were randomly selected and grouped. Patients in the treatment group took dong medicine five-flavor anti-diarrhea soup combined with melalazine enteric tablets (30 patients). Patients in the control group received oral melalazine intestinal-soluble tablets (30 patients). Changes in the traditional Chinese medical syndrome scores, Baron endoscopic scores, Mayo scores, serum complement C3 and C4, serum interleukin-23 and interleukin-17 were recorded before and after 8 w of treatment in the treatment and control groups, and total traditional Chinese medicine symptoms were observed and recorded. The treatment group was better than the control group in improving the total points of traditional Chinese medical symptoms, Mayo and Baron scores and reducing complement C3 and C4 and serum interleukin-23 and interleukin-17 levels, which were demonstrated as statistically significant (p<0.05). The treatment effects of dong medicine five-flavor anti-diarrhea soup combined with melalazin on the chronic recurrence type (spleen deficiency and dampness accumulation type) ulcerative colitis of the treatment group are better that of the control group regarding the Mayo scores, Baron endoscopic scores, remission of various symptoms of traditional Chinese medicine, reduction of serum complement and C3, C4, interleukin-23 and interleukin-17 levels.