Effects Of The Traditional Chinese Medicine, Guilu Erxian Gum, On Exercise Performance, Myocardial Protection And Osteoporosis Relief In Chemotherapy Mice

Abstract

Purpose: To investigate the effects of Guilu Erxian Gum on exercise performance, myocardial protection and osteoporosis relief in chemotherapy mice. Methods: 21 ICR mice were assigned to control group (CON, N = 4), Guilu Erxian Gum supplement group (CON+GEG, N = 5), doxorubicin chemotherapy treatment group (DOX, N = 6), and Guilu Erxian Gum and doxorubicin group (DOX + GEG, N = 6). CON+GEG and DOX + GEG group were received 100 mg/kg/times of Guilu Erxian Gum twice a day in the 2nd-4th and 7th weeks. Dox and DOX + GEG group were injected 3 mg/kg/times of doxorubicin twice a week in the 2nd-4th weeks. All groups performed exhausted swimming test in the 7th week. In the 8th week, mice were sacrificed, and their blood, urine, femurs, and myocardial tissue were collected for analysis. Independent one-way ANOVA was used to analyze the differences among groups on exhausted swimming time, blood flow, bone density and body weight of 8th week, respectively. Results: The swimming exhaustion time of CON (320.5 ± 23.5 sec) and CON+GEG (303.5 ± 22.5 sec) groups were significantly higher than that of DOX (242.0 ± 21.5 sec) and DOX + GEG (290.5 ± 23.0 sec) groups (p < .05). The blood flow and antioxidant capacity of CON+GEG (653.5 ± 19.4 AU) group were significantly higher than those of CON (597.5 ± 18.2 AU) group (p < .01). The bone density of DOX (4.2 ± 1.6%) group was lost and its myocardial tissue showed oxidative stress and inflammation, however, DOX + GEG (7.1 ± 1.4%) group had an alleviated effect (p < .05). Conclusion: GEG can improve blood circulation, antioxidant capacity of myocardial tissue, and alleviate the side effects of chemotherapy on body weight, exercise performance, inflammation, and bone density.