Abstract
The potency of the substrate analogue inhibitor H77 has been investigated in vivo in anaesthetized rats and conscious dogs. ID50 values have been determined against rat, dog and pig renins injected into rats and against dog renin injected into dogs. In the rat H77 was most potent against injected dog renin (ID50 0.53 mg/kg/h), of intermediate potency against injected pig renin (ID50 1.1 mg/kg/h) and least potent against injected rat renin (ID50 40 mg/kg/h). H77 was more potent against dog renin injected into dogs than into rats (ID50 against dog renin in dogs 0.056 mg/kg/h). At infusion rates up to 0.5 mg/kg/h in dogs and 50.0 mg/kg/h in rats H77 was without effect on the pressor response to angiotensin I. Hence H77 appears to be a specific inhibitor of dog, rat and pig renins in vivo, the dose of H77 depending upon the type of renin injected and the species of the recipient animal.
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