Abstract
Although, vascular grafts are frequently applicated in the cardiac surgery, the storage protocols need further improvement against ischemia/reperfusion (IR) injury. Endothelial dysfunction may result in postoperative graft failure and promote late graft vasculopathy. Low oxygen tension elicits a variety of complex cellular responses by altering the activity of many signaling pathways, such as the oxygen dependent prolyl hyroxylase-domain containing enzymes (PHD). Reduction of PHD-activity during hypoxia leads to stabilisation and accumulation of hypoxia inducible factor 1-α (HIF1α), a transcription factor which regulates the expression of target genes in response to hypoxia. This study is designed to characterize the effects of dimethyloxalylglycine (DMOG) on the vasomotor responses of isolated rat aorta submitted to hypoxia/reoxygenation and on isolated aortic vascular smooth muscle cells (VSMC) in a model of cold ischemia/warm reperfusion.
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