Abstract
An assessment of the behavioral effects of acutely administered anti-cholinesterase compound O-ethyl- N-dimethyl phosphoramidocyanidate (tabun), to male rats was performed in three studies across five dose levels (100–198 μg/kg, sc). Doses of 122 μg/kg or greater produced conditioned flavor aversions. Spontaneous locomotor activity was significantly decreased at doses of 122 μg/kg or greater when compared to vehicle control levels. When administered doses of 168 μg/kg or greater, rats exhibited significant decrements in rotarod performance. In addition, the LD50 of tabun was determined to be 240 μg/kg. Signs of cholinergic intoxication were not apparent until 144 μg/kg tabun or more were given. Behavioral effects were thus obtained at doses that were between 54 and 71% of the LD50.
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