Abstract
The effects of the low‐dose oral contraceptive combination 0.150 mg desogestrel+0.020 mg ethinylestradiol (EE) on serum cholesterol (total cholesterol, HDL‐cholesterol and % HDL‐cholesterol in total cholesterol), sex hormone binding globulin (SHBG), apolipoprotein A‐I and glycosylated proteins and plasma antithrombin III activity were studied in 25 healthy fertile women. Blood samples were taken before treatment and after 1,3,6 and 12‐15 treatment cycles. The contraceptive combination had no effect on total cholesterol, glycosylated proteins or antithrombin III activity. During treatment there were small but significant increases in HDL‐cholesterol, % HDL‐cholesterol in total cholesterol and apolipoprotein A‐I and a substantial increase in SHBG. Thus the combination 0.150 mg desogestrel+0.020 mg EE appears to have no adverse effects on lipid metabolism, serum glycosylated proteins and plasma antithrombin III activity.
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