Abstract
Hemorrhagic shock leads to the appearance of substances in plasma that depress Na/K ATPase activity, an effect that could be related to significant morbidity and mortality. Recently, some findings indicated that purine nucleosides such as guanosine, inosine or adenosine might prolong survival in shocked rats, an effect potentially related to the stimulation of Na/K ATPase activity. This study aimed to evaluate the effects of intravenous administration of guanosine or inosine combined with lactate Ringer solution (LR) on hemodynamic and oxygenation parameters and survival in an experimental model of hemorrhagic shock (HS).
Highlights
Sepsis is primarily a disease of the aged and 60% of sepsis occurs in patients older than 65 years, 80% of deaths due to sepsis occur in this age group
The purpose of the study is to elucidate the immunological changes that occur in Klotho mice after sepsis in order to identify therapeutic targets for sepsis that occurs in aged individuals
The neonatal hypotonia rate is significantly higher in the Magnesium sulfate therapy (MST) group (3.57, 95% cardiac index (CI) 2.89 to 4.42), significant heterogeneity of the control group may be a valuable confounding factor
Summary
Sepsis is primarily a disease of the aged and 60% of sepsis occurs in patients older than 65 years, 80% of deaths due to sepsis occur in this age group. The aim was to evaluate the association between admission levels of CFD and severe sepsis outcome in patients hospitalized in intensive care utilizing the new assay. Implementation of a ventilator-associated pneumonia (VAP) bundle as a performance improvement project in the critical care units for all mechanically ventilated patients aiming to decrease the VAP rates over the study period at four major teaching hospitals in Damascus. The combination of high positive end-expiratory pressure (PEEP) and low tidal volume (VT) decreases some risks of mechanical ventilation, including pulmonary overdistention, damage due to cyclic opening and closing of the alveoli, and inflammatory responses that can lead to multiple-organ dysfunction. The timing and location for optimal post-ICU rehabilitation programs remain to be established
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