Abstract
Objectives The influences of Hb variants on HbA 1c values can cause mismanagement of diabetes; therefore, the effects of Hb E, H, and G-Taichung variants were evaluated. Designs and methods HbA 1c values of 2105 samples, including 37 samples with Hb E, H and G-Taichung variants identified by Hb electrophoresis and the PCR sequence, were evaluated by the ion-exchange (Bio-Rad Variant™ II Turbo analyzer) and boronate affinity (Primus CLC 385 analyzer) high performance liquid chromatography (HPLC) methods. Results In the patients with the Hb E and H variants, their HbA 1c values determined by ion-exchange HPLC were significantly higher than those by boronate affinity HPLC. However, there were no significant differences of the HbA 1c values in the patients with the Hb G-Taichung variant. Conclusions The HbA1c levels might be interfered by the Hb E and H variants, but not the Hb G-Taichung variant, measured by the Bio-Rad Variant™ II Turbo analyzer.
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