Effects of the glycerophosphate-polylactic copolymer formation on electrospun fibers

Abstract

Poly-lactic (PLA) porous fibers are widely used in tissue engineering scaffolds and many other fields. Non-solvent induced phase separation is one of the best way for preparation of porous fiber. It is difficult to obtain the PLA electrospun porous fibers by phase separation. In this paper, glycerophosphate-polylactic copolymer (GP-PLA) are synthesized with sodium glyceryl phosphate and L-lactide to produce porous fibers. Furthermore, the Gel permeation chromatography (GPC), FT-IR and 1H-NMR are applied for characterizing the obtained copolymers. Thermogravimetric (TG) measurements indicate that the thermal stability of GP-PLA is lower than that of linear PLA. Under 30% humidity, porous GP-PLA fibers are obtained by electrospinning method, the scanning electron microscopy (SEM) refers that through the modification of the molecular structure, GP-PLA fibers are more porous under the same condition. The water contact angle is increased coming with the increase of GP contents. Hydrophilic porous GP-PLA fibers are obtained via solvent phase separation. The relationship between hydrophilicity and surface morphology of materials is further explained by Atomic Force Microscope (AFM). GP-PLA has a potential application in the field of scaffold for tissue engineering.