Abstract
The study was conducted with the participation of 47 healthy subjects and 48 schizophrenia patients. The different effects of Val158Met polymorphism have been found in the control and patients groups. The increased N100 amplitude and minimal number of the error responses in oddball task were revealed in healthy subjects with Val/Val genotype. In patients group Val/Val genotype was related to the decreased N100 amplitude and worse performance of oddball task.
Highlights
Of the Ministry of Health of the Russian Federation, Moscow, Russia Summary
The study was conducted with the participation of healthy subjects and schizophrenia patients
The different effects of Val158Met polymorphism have been found in the control and patients groups
Summary
Of the Ministry of Health of the Russian Federation, Moscow, Russia Summary. The study was conducted with the participation of healthy subjects and schizophrenia patients. Полиморфизм Val158Met гена КОМТ оказывает влияние на активность фермента таким образом, что у «валинового» варианта активность КОМТ в 2-4 раза выше, чем у «метионинового» [2], и это обуславливает более низкое содержание ДА у носителей аллеля Val. Изучение эффектов полиморфизма Val158Met гена КОМТ на параметры N100 является актуальным для изучения центральных механизмов ранних этапов внимания в норме и при шизофрении и выявления маркеров риска заболевания. Задачей настоящего исследования явилось изучение эффектов полиморфизма Val158Met в отношении амплитуды N100 и особенностей выполнения теста «oddball» в норме и при шизофрении.
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