Abstract
Effects of the complex of magnesium and chromium citrates on the carbohydrate metabolism in the blood of rats with experimental diabetes mellitus
Highlights
The article presents the results of investigation of the influence of the complex of magnesium (Mg2+) and chromium (Cr3+) citrates on the activity of carbohydrate metabolism key enzymes, and on the concentration of insulin and C-peptide in the blood of rats with experimental diabetes
All experimental animals were divided into 5 groups: control group (CG), with 5 non-diabetic control rats, the diabetic group (DG), with 5 diabetic rats without any treatment for the disease and two research groups (RG), with 5 diabetic rats each treated by complexes of magnesium and chromium salts
Conducted investigation of the activity of main enzymes of carbohydrate metabolism in red blood cells of rats of the first experimental group showed the tendency to the decrease of the glucose-6-phosphate dehydrogenase (G6PDH) activity on 14 % and the increase of the lactate dehydrogenase (LDH) activity on 1.6 % comparing to the results in CG
Summary
The article presents the results of investigation of the influence of the complex of magnesium (Mg2+) and chromium (Cr3+) citrates on the activity of carbohydrate metabolism key enzymes, and on the concentration of insulin and C-peptide in the blood of rats with experimental diabetes. The complex of magnesium and chromium citrates, which was added with water to the animals’ diet during four weeks, led to a positive normalizing effect It was shown by a credible increase of insulin and C-peptide concentrations and followed by a decrease of glucose concentration in the blood plasma. У статті наведені дані досліджень впливу комплексу цитратів магнію (Mg2+) і хрому (Cr3+) на активність ключових ензимів вуглеводного обміну, а також концентрацію інсуліну і С-пептиду в крові щурів з експериментальним цукровим діабетом. Досліджували активність глюкозо-6-фосфатдегідрогенази (Г-6-ФДГ) і лактатдегідрогенази (ЛДГ) у лізатах еритроцитів, концентрацію глюкози, інсуліну і С-пептиду у плазмі крові дослідних тварин. Це проявлялось вірогідним підвищенням концентрації інсуліну і С-пептиду із наступним зниженням концентрації глюкози у плазмі крові
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