Abstract
Studies were made on the acute and subacute toxic effects of the co-mutagen norharman when given orally to male Fischer strain rats. Animals were given diets containing 1500 ppm of norharman for 28 days, and 3 or 6 animals were killed for examination on days 0, 1, 3, 7, 14, 21, and 28. During norharman administration, the body weight and food and water intakes of the rats gradually decreased, the kidney weight increased significantly and blood urea nitrogen also increased. Norharman caused segmental coagulative necrosis of the tubular epithelium of the kidney, which increased in severity and extent with the period of treatment, but glomerular changes were negligible. In the testis, the germinal epithelium showed decreased spermatogenic activity after day 7. Norharman had no detectable effects on other organs.
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