Abstract
A single dose of the direct-acting alkylating agent N-methyl- N-nitrosourea (NMU) caused a temporary fall in spleen lymphocyte numbers and therefore temporarily reduced and delayed the development of specific antigen binding cells following immunization with horse erythrocytes. However, though the skin allograft response appears to be permanently impaired in NMU-treated Xenopus, spleen cell antigen binding capacity following low-dose or high-dose immunization returned to the control levels once the spleen lymphocyte population had regenerated. By contrast, a comparable single dose of the related, but more stable, carcinogen N-dimethylnitrosamine had no such effects on Xenopus lymphoid tissues, on skin allograft survival time, or on spleen cell antigen binding capability.
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