Abstract
Male Lewis rats (two groups of 10) received intracerebroventricular injections of either AM 630 (vehicle, 2.5, 5, 10 and 20 μg) or AM 281 (vehicle, 5, 10, 20 and 40 μg) following overnight food deprivation. The CB2 antagonist AM 630 failed to block deprivation-induced intake at 0.5, 1, 2, 4 and 6 h. The CB1 antagonist AM 281 significantly blocked intake following 20 μg (1 h) and 40 μg (1, 2, 4 and 6 h). Results are discussed with respect to cannabinoid receptor systems’ involvement in ingestion and the differential pharmacological profiles of AM 630 and AM 281.
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