Abstract
The effects of the aromatase inhibitor fadrozole on oogenesis, spermatogenesis and gonadal development in coho salmon Oncorhynchus kisutch were investigated. Both fe. males and males were implanted intraperitoneally with single silicone pellets containing the aromatase inhibitor fadrozole (CGS 16949A) at dosages of 10 mg•kg·1, 100 mg•kg·1 and 500 mg• kg·1, respectively. After 44 d, histological examination showed that females treated at dosages of 100 mg•kg·1 and 500 mg•kg· 1 had gonads with atretic oocytes. Conversely, control females had ovaries filled with synchronously developing oocytes. Both average ovarian cross-sectional areas and average oocyte diameters in the treated groups were smaller than those in the control. It is suggested that the aromatase inhibitor fadrozole affected oogenesis and ovarian development in coho salmon. The results did not show any significant differences in spermatogenesis and testicular development between treated and control males, except for the males which received a dosage of 100 mg·kg·1, a small number of which had testes which were further developed than those in the control.
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