Abstract
1. 1. The anticonvulsant, trimethadione, (0.1–20 mM) was tested for effects on the bursting pacemaker activity of neuron R15 in the abdominal ganglion of Apylsia californica. 2. 2. Two responses were observed: hyperpolarization of the trough of the bursting pacemaker potential and complete blockade of bursting. 3. 3. The responses could occur independently or in combination in any given preparation over the same range of TMO concentrations. 4. 4. Simultaneous recordings from two or more neurons disclosed that both responses could be accounted for by the activation of a known synaptic input with tonic inhibitory effects. 5. 5. The utility of the abdominal ganglion as a test system for convulsant and anticonvulsant drugs is discussed.
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