Abstract
The actions of noradrenaline and isoprenaline and of the α-adrenoceptor antagonists dihydroergotamine (DHE) and phentolamine, on lipolysis in isolated fat cells from the rat, guinea pig, dog and man have been investigated. In isolated rat fat cells the efficacy of noradrenaline in stimulating lipolysis was equal to that of isoprenaline. In guinea pig, dog and, particularly in human fat cells the maximal effects elicited by noradrenaline were lower than those elicited by isoprenaline. In these tissues the efficacy of noradrenaline was elevated to isoprenaline levels in the presence of low concentrations of DHE or phentolamine. DHE alone produced a weak stimulation of lipolysis in rat fat cells and an intense stimulation in canine fat cells; phentolamine was without effect. In concentrations of 10 −5 M and above both DHE and phentolamine inhibited catecholamine stimulated lipolysis in fat cells from all species tested, probably as a result of unspecific effects.
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