Abstract
To investigate the effects of administering persimmon vinegar, Sprague-Dawley male rats were fed either an AIN-93 diet (N-C,control), control diet plus ethanol (N-E, 4g ethanol/kg bw), N-E plus Persimmon-Vinegar (N-G1, 1§¢/kg bw) or N-E plus Persimmon-Vinegar (N-G2, 2§¢/kg bw) for 8 weeks. Serum triglyceride levels were increased in the N-E group and were decreased significantly in the N-G1 groups. Particularly, liver total cholesterol levels were significantly decreased in the N-G1 and N-G2 groups compared with N-E groups. Liver HDL cholesterol and total cholesterol levels were significantly higher in the N-G2 groups compared with N-E groups. AIAC(acid insoluble acyl-carnitine) levels in Serum and liver were significantly higher in the N-G1 and N-G2 groups compared with N-E groups. Carnitine palmitoyltransferase-I mRNA levels in liver increased significantly in the N-G1 and N-G2 groups. Acyl CoA synthetase mRNA levels in liver decreased in the N-G2 groups. Also, administration of persimmon-vinegar served as an activator of alcohol metabolism. These results suggest that administration of persimmon vinegars have a beneficial effect on lipid profiles and increases alcohol metabolisms in rats.
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