Effects of the 5-HT 3 receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice

Abstract

The effects of the 5-HT 3 receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice were examined. The non-competitive NMDA receptor antagonists ketamine (1.0–10 mg/kg, i.p.) and dizocilpine (0.1 and 0.2 mg/kg, i.p.) each produced a place preference in a dose-dependent manner. The ketamine (10 mg/kg)- and dizocilpine (0.2 mg/kg)-induced place preferences were dose-dependently blocked by pretreatment with ondansetron (0.03–0.1 mg/kg, s.c.). These results suggest that 5-HT 3 receptor may be involved in the development of the place preferences produced by ketamine and dizocilpine.