Abstract
目的 汉防己甲素(TET)联合大容量全肺灌洗术(WLL)对尘肺病患者生命质量和氧化应激指标的影响.方法 128例尘肺患者随机分为治疗组和对照组,治疗组64例、对照组64例,对照组给予WLL,治疗组在WLL的基础上加用汉防己甲素片,用药时间共6月.观察2组患者的肺功能、生命质量、氧化应激及不良反应情况.结果 与治疗后对照组比较,治疗后治疗组最大通气量(MVV％)、第1秒时间肺活量(FEV10％)、用力肺活量(FVC％)、FEV1.0/FVC％、一氧化碳弥散量(DLco％)升高,差异有统计学意义(P＜0.05).与治疗后对照组比较,治疗后治疗组呼吸症状、疾病影响的差异有统计学意义(P＜0.05),与治疗后对照组相比较,治疗后治疗组谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)活力升高,过氧化氢酶(CAT)活力及MDA含量降低,差异均有统计学意义(P＜0.05).与治疗前比较,治疗后治疗组GSH-PX、SOD、CAT活力升高,MDA降低,差异有统计学意义(P＜0.05).结论 TET与WLL协同具有一定的提高尘肺病患者肺功能,改善患者生命质量的效果,其作用机理可能与其抗氧化应激作用有关。
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