Abstract
IN MEN (1) AND IN MALE rats (2) advancing age is associated with decreased levels of eosinophiles in the anterior pituitary. Since this gland plays such an important role in many bodily processes throughout life, it seemed desirable to ascertain if this decrease could be prevented or at least modified by experimental methods. Several facts indicated that male sex hormone might exert such an effort. It is known that the anterior pituitaries of male rats are characterized by higher levels of both eosinophiles and basophiles and lower levels of chromophobes than are found in the glands of females (3, 4). Furthermore, injection of testosterone propionate into young female rats for a sufficient period induces an increase in the levels of the eosinophiles and basophiles. As a result the cellular pattern in the anterior pituitaries of these animals more nearly resembles that of their untreated littermate brothers than of their untreated sisters (5).
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