Abstract

IN PREVIOUS communications from this laboratory (I, 2) it was reported that the action of parenterally administered testosterone propionate on the ovaries of female rats varied according to the phase of the estrous cycle at which the first injection was given. When given during late diestrus the ovaries were small and contained many follicles in various stages of development but they lacked recent corporalutea. The uteri were enlarged and the endometria hyperplastic. The vaginae were mucified, and the mammae presented evidence of duct proliferation with a marked increase of fibrous tissue. There was, however, no evidence of acinar growth. Similar organ changes, with the exception of the ovaries, were found in castrates treated with testosterone (3). When the initial injection was given during late estrus the ovaries were distinctly enlarged, due to the presence of hypertrophied corpora lutea and follicles in various stages of development

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