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Abstract
The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects. MOR exposure was similar, with an area under the curve from 0 h to infinity (AUC0-∞) treatment ratio for MOR+TDF/MOR of 1.01 (90% confidence interval, 0.97 to 1.06). No relevant differences were observed regarding plasma exposure of metabolites. Renal clearances of MOR and its metabolites were not affected by TDF. No unexpected safety or tolerability issues were observed.
Highlights
The effects of multiple-dose administration of tenofovir disoproxil fumarate (TDF) on the pharmacokinetics of morinidazole (MOR) were compared in healthy subjects
It has been reported that morinidazole undergoes extensive metabolism, primarily via N-glucuronidation and o-sulfation [3]
The main transporters involved in the renal secretion of drugs in humans include organic anion transporter (OAT) 1, OAT 3, and organic cation transporter (OCT) 2 [5,6,7]
Summary
Guolan Wu,a,b Wenling Tang,c Duo Lv,a,b Lihua Wu,a,b Huili Zhou,a,b Xi Yang,d Yunliang Zheng,a,b You Zhai,a,b Jianzhong Shentua,b aResearch Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China bZhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China cCollege of Medicine, Zhejiang University, Hangzhou, China dDepartment of Pharmacy, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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