Abstract
Diabetes is a worldwide metabolic diseases that requires adjustments in the blood glucose. Cornstarch is one kind of resistant starch, which helps to control postprandial glucose, and is a desired alternatives of carbohydrates for developing functional food. Herein, a cornstarch-based functional diet (CFD) was developed, and in this study we investigated the effects of CFD supplemented with tea polyphenols and EGCG on blood glucose and intestinal flora in diabetic mice. The results showed that diabetic mice had significant weight loss and serious hyperglycemia. The CFD or CFD supplemented with tea polyphenols and EGCG resulted in a trend toward reduced fasting blood glucose. Furthermore, diabetes had significant intestinal flora disturbance, with particularly increased levels of Bacteroidaceae, Helicobacteraceae, Ruminococcaceae, Enterobacteriaceae, Rikenellaceae and Saccharibacteria_genera_incertae_sedis, and decreased Prevotellaceae, Coriobacteriaceae, Bifidobacteriaceae and Verrucomicrobiaceae. Interesting, CFD supplemented with EGCG significantly increased levels of Prevotellaceae and Coriobacteriaceae, and decreased Lachnospiraceae, Helicobacteraceae, Ruminococcaceae and Saccharibacteria_genera_incertae_sedis compared to controls. CFD supplemented with tea polyphenols significantly increased the Coriobacteriaceae and Bifidobacteriaceae. The comprehensive analysis indicated that tea polyphenols and EGCG supplementation improved glucose metabolism, and reversed the sick changes of intestinal flora, suggesting they are two valuable additions to promote nutritional value of CFD.
Highlights
The results suggested that tea polyphenols and EGCG exerted greater inhibitory effects on the digestion and absorption of cornstarch in vivo
Our previous test in vitro illustrated that 0.5% EGCG and 0.5% tea polyphenols supplementation were capable of reducing the hydrolysis rate of cornstarch by 25.1% and 20.6%, respectively
The results of this study showed that cornstarch-based functional diet (CFD) supplemented with tea polyphenols and EGCG resulted in a trend toward increased body weight levels, but reduced feed intake level
Summary
Controlled frequent high blood glucose leads to the long-term complications of diabetes, including oxidative stress (Damasceno et al, 2002), glucolipid metabolic disorder (Stefano et al, 2016). It is well-known that ordinary starchy food is a threat to diabetes patients, but resistant starch may be a desired alternatives (Nugent, 2005). Cornstarch is one kind of resistant starch, and it contains more than 50% content of resistant starch (Nugent, 2005; Zhang et al, 2018a). We can use cornstarch to develop a new kind of functional food for controlling postprandial glucose. Our previous studies showed that tea products (tea polyphenols, epigallocatechin gallate (EGCG, one major component of tea polyphenols), matcha or instant tea) exerted great inhibitory effects on the hydrolysis of cornstarch in vitro (Zhang et al, 2018a), suggesting tea products may be a desired food supplement for developing cornstarch-based functional food
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
