Abstract
Transcranial direct current stimulation (tDCS) is an emerging brain intervention technique. However, the effects of tDCS on stroke patients are unclear. In this study, Granger Causality (GC) is used to construct brain functional networks of the tDCS group (9 cases) and the sham tDCS group (11 cases). Some parameters of brain functional networks are analyzed comparatively, such as degree, clustering coefficient, betweenness centrality, characteristic path length, and efficiency. In tDCS group, the results show that the distribution of degree changes greatly in left prefrontal lobe and left temporal lobe regions, the distribution of betweenness centrality transfers, characteristic path length decreases, clustering coefficient and efficiency increase significantly ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$p< 0.05$ </tex-math></inline-formula> ) after stimulation. However, there is no significant difference in sham tDCS group. In this study, the positive effects of tDCS on the therapeutic of stroke are clarified and the evidence for the effects of tDCS on stroke is provided.
Highlights
Stroke is a disease with a high incidence worldwide and a major cause of disability which damages the motor function and is extremely detrimental to daily life and work [1]– [3]
Wang et al.: Effects of Transcranial direct current stimulation (tDCS) on Brain Functional Network of Patients After Stroke patients was assessed at 5 days and 3 months after stroke, there was no significant difference between tDCS group and sham tDCS group
The results show that the brain functional network of tDCS group is improved, which suggests that tDCS may play an active role in the rehabilitation of stroke patients
Summary
Stroke is a disease with a high incidence worldwide and a major cause of disability which damages the motor function and is extremely detrimental to daily life and work [1]– [3]. Transcranial direct current stimulation (tDCS) has been studied as a non-invasive neuromodulation technique in the fields of geometric change and clinical application [9], [10]. TDCS is extremely convenient that the anode is directly placed on the lesion site to improve cortical excitability which plays a role in assisted rehabilitation [11]. It has been considered as a very promising method which has the characteristics of high safety and portability in the field of neurological rehabilitation [9], [10].
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