Abstract
In the present study, the medicinal plant Tanacetum polycephalum, was used to evaluate its effect on oxidative stress and memory deficit caused by PTZ in the rats. Twenty-four rats were randomly categorized into four groups: control negative under treatment with PTZ (sub-threshold dose 35 mg kg−1 for 1 month), control positive under treatment with phenobarbital (PB 30 mg kg−1), and two PTZ groups under treatment with T. polycephalum extract (TPE 300, and 600 mg kg−1). Standard passive avoidance test was used to evaluate memory and learning. After behavioral evaluation, the rats were anesthetized and their brains were removed; following the preparation of brain homogenates, oxidative stress parameters were evaluated using specified methods. It was found that step-through latency in passive avoidance test in PTZ group receiving TPE was greater than that of PTZ group. In addition, brain lipid peroxidation (malondialdehyde) and nitric oxide level in TPE-treated group was significantly lower and glutathione activity and superoxide dismutase level were significantly greater in comparison to PTZ group. Our results showed that TPE could prevent memory deficit and ameliorate hippocampal oxidative stress in PTZ-kindled rats.
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