Effects of tamsulosin hydrochloride sustained release capsule in improving symptoms and quality of life of patients with indwelling double-J ureteral stents

Abstract

Objective To investigate the influence of tamsulosin hydrochloride sustained release capsule in improving symptoms and quality of life of patients with indwelling double-J ureteral stents. Methods From March 2016 to June 2017, 96 patients with indwelling double-J ureteral catheter were randomly divided into control group and observation group, with 48 patients in each group. The control group did not take drugs after operation, and the patients in the observation group were treated with tamsulosin hydrochloride sustained release capsule once a day, totally for 1 month. All the enrolled patients completed the Ureteral Stent Symptom Questionnaire (USSQ), the International Prostate Symptom Score (IPSS) , quality of life (QOL), visual analogue scale (VAS) as well as the Overactive Bladder Symptom Score (OABSS) on the day after the removal of the stent 4 weeks after treatment. Results The mean urinary symptom index score, the pain index score, the sex index score and the ability index of work score of the observation group were (25.23±4.35), (14.58±2.84), (3.82±1.03) and (12.83±3.85) , lower than the score (31.29±4.48), (30.39±3.91), (5.83±1.94) and (18.81±5.03) of the control group. The storage stage score and IPSS total score were respectively (3.31±1.38) and (6.87±2.94), lower than the score (6.14±2.03) and (10.31±2.26) of the control group. The QOL, VAS, OABSS score were (1.54±0.93 ), (1.95±1.07) and (4.31±1.28), lower than the score(3.24±0.93), (4.04±1.23) and (9.29±2.87) of the control group. As opposed to the control group, it was observed that observation group prominently improved and the scores were statistically significant(P<0.05). Conclusions Tamsulosin hydrochloride sustained release capsule can significantly improve the related symptoms of indwelling double-J ureteral stents and prostatic symptoms, reduce pain, improve patient's quality of life. Key words: Urinary Catheterization; Adrenergic alpha-Antagonists; Signs and Symptoms; Quality of Life