Abstract
Objective: CC is commonly used to either provoke ovulation in anovulatory patients, or to increase the number of pre-ovulatory follicles in ovulatory patients prior to IUI. However, pregnancy rates following induction with CC and IUI are lower than expected for the number of follicles produced. This may be a result of the anti-estrogenic effect of CC on the endometrium. Tx has been previously been shown to act as an estrogen agonist on endometrial cells causing, after prolonged use, endometrial hyperplasia. In this study we investigated the potential positive effect of Tx on the endometrium, and pregnancy rates in patients treated with CC prior to IUI.
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