EFFECTS OF TAMOXIFEN OR LETROZOLE ON LIPID PROFILE, VITAMIN D AND ESTRADIOL SERUM LEVELS IN OBESE POSTMENOPAUSAL WOMAN WITH BREAST CANCER

Haeder Abdulhafith Al-Biati,Anwar Noori Mahmood,Ahmed Salih Sahib

doi:10.22159/ijpps.2017v9i2.14918

Abstract

Objective: Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset. Women who are obese continue to have higher levels of estrogen than women of normal weight even after treatment with hormone-suppressing drugs, raising the possibility that they might benefit from modification or changes to their treatment. The aim of this work was to study the effect of letrozole compared to tamoxifen on serum estradiol and, vitamine D and metabolic profile in Iraqi obese postmenopausal women with breast cancer.Methods: A hospital-based case-control study was carried out at Baquba teaching hospital, Diyala, Iraq. The analyzed variables were: age, lipid profile including total cholesterol; triglycerides, HDL-C, blood sugar, estradiol, and serum vit D. Descriptive statistics and testing of hypothesis were used for the analysis using mean±SD test P≤0.05. Results: Lipid profile, serum estradiol showed significant variability among the studied group in this study and serum vit D show significant differences between groups in postmenopausal obese with breast cancer taking tamoxifen.Conclusion: Treatment of obese women with breast cancer with tamoxifen or letrozole had neglected effects on metabolic parameters including lipid profile and blood sugar, both agents decrease serum estradiol level in treated patients, and most importantly, the significant positive effect of tamoxifen on serum vitamin D level compared to negative effect of aromatase inhibitor drug letrozole.

Highlights

Breast cancer is a worldwide major public health problem in women population, affecting both the developing and developed countries and comprising 18% of all female cancers; more than 1.2 million cases are diagnosed every year, affecting 10-12% of the female population and accounting 500,000 deaths per year worldwide [1]
The aim of this work was to study the effect of letrozole compared with tamoxifen on serum level of estrodiol, vitamin D level and other biochemical parameters in Iraqi obese postmenopausal patients with breast cancer
This study was carried out at Baquba teaching hospital, Diyala, Iraq; and approved by local institutional scientific and ethical committee; an informed consent was taken from all participants; 30 postmenopausal women newly diagnosed with breast cancer, who were visited the consultation clinic participated in the study

Summary

Introduction

Breast cancer is a worldwide major public health problem in women population, affecting both the developing and developed countries and comprising 18% of all female cancers; more than 1.2 million cases are diagnosed every year, affecting 10-12% of the female population and accounting 500,000 deaths per year worldwide [1]. It is well established that women having low-income and worse socioeconomic conditions are at increased risk to develop breast cancer and have lower rates of survival in already existed breast cancer [2]. Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset [5]. Another risk factor for breast cancer is a deficiency of 25-OH vitamin D. The aim of this work was to study the effect of letrozole compared with tamoxifen on serum level of estrodiol, vitamin D level and other biochemical parameters in Iraqi obese postmenopausal patients with breast cancer

Methods

Results

Discussion

Conclusion