Abstract
Aldehydehydrogenase is a NAD(P)-dependent enzyme with wide distribution virtually in all animal tissues (Vasiliou and Marselos, 1989; Lindahl, 1992). Different consti- tutiveexpressed ALDHs are found in liver, stomach, brain, kidney, skin and eye (Vasil and Marselos, 1989; Pappas et al., 1997). In general, ALDHs are located especially in org with a high content of epithelial cells. An increased interest has been shown r the last years for aldehyde dehydrogenase-3 (ALDH3) activity in the cornea where h higher constitutive specific activity is detected compared to the liver cells (Boesct al., 1996). High levels of ALDH3 activity occurs in the cornea from baboon, cow, hn, opossum, pig and sheep (King and Holmes, 1997). The same study reports also tpresence of ALDH1 as the 1-2% of human lens soluble protein. Furthermore, retina and real pigment epithelial (RPE) cells have been shown to play an important protective role fthe photosensitive cells of the eye against photo- and chemical toxicity.
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