Abstract
We aimed to evaluate the efficacy of tadalafil 5mg once-daily treatment on testosterone levels in patients with erectile dysfunction (ED) accompanied by the metabolic syndrome. A total of 40 men with metabolic syndrome were evaluated for ED in this study. All the patients received 5mg tadalafil once a day for 3months. Erectile function was assessed using the five-item version of the International Index of Erectile Function (IIEF) questionnaire. Serum testosterone, follicle-stimulating hormone and luteinising hormone levels were also evaluated, and blood samples were taken between 08.00 and 10.00 in the fasting state. All participants have three or more criteria of metabolic syndrome. At the end of 3months, mean testosterone values and IIEF scores showed an improvement from baseline values (from 3.6±0.5 to 5.2±0.3, from 11.3±1.9 to 19±0.8 respectively). After the treatment, serum LH levels were decreased (from 5.6±0.6 to 4.6±0.5). There was significantly difference in terms of baseline testosterone and luteinising hormone values and IIEF scores (p<.05). Based on our findings, we recommend tadalafil 5mg once daily in those men with erectile dysfunction especially low testosterone levels accompanied by metabolic syndrome.
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